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Tuesday, July 21, 2020 | History

3 edition of Membrane-mediated cytotoxicity found in the catalog.

Membrane-mediated cytotoxicity

proceedings of a Cetus-UCLA Symposium held in Park City, Utah, March 9-16, 1986

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Published by Liss in New York .
Written in English

    Subjects:
  • Toxins -- Physiological effect -- Congresses.,
  • Cell membranes -- Congresses.,
  • Antibody-dependent cell cytotoxicity -- Congresses.,
  • Cytotoxicity, Immunologic -- congresses.,
  • Cytotoxins -- congresses.

  • Edition Notes

    Includes bibliographies and index.

    Statementeditors, Benjamin Bonavida, R. John Collier.
    SeriesUCLA symposia on molecular and cellular biology ;, new ser., v. 45
    ContributionsBonavida, Benjamin., Collier, R. John.
    Classifications
    LC ClassificationsQP631 .M45 1987
    The Physical Object
    Paginationxxiii, 586 p. :
    Number of Pages586
    ID Numbers
    Open LibraryOL2738958M
    ISBN 10084512644X
    LC Control Number86033775

    The regulation of T-cell-mediated immune responses depends on the phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) on T-cell receptors. Although many details of the signaling cascades are well understood, the initial mechanism and regulation of ITAM phosphorylation remains unknown. We used molecular dynamics simulations to study . The stimulation of T‐cell proliferation, CTL and macrophage cytotoxicity, and NK activity by Se may be a result of the ability of Se to enhance the expression of the α and/or β subunits of the IL‐2R on these activated immune cells [, , ].

    Membrane-mediated cytotoxicity: Proceedings of a Cetus-UCLA Symposium held in Park City, Utah, March , (UCLA symposia on molecular and cellular biology) Benjamin Bonavida, R. John Collier Published by Liss (). Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are effectors of cell-mediated cytotoxicity towards virally infected and tumourigenic cells. The integrin leukocyte function associated antigen-1 (LFA-1) is required for the adhesion of effector cells to their targets. In addition, LFA-1 transduces signals resulting in actin polymerization. We show that in both .

      Uckun, F. M. et al. in Membrane-mediated Cytotoxicity UCLA Symposium on Molecular and Cellular Series (eds Gale, R. P. & Champlin, R.) 45, – Immunology: A common form of killing. Affiliations. Mechanisms of Tumour Immunity Unit, MRC Centre, Hills Road, Cambridge, CB2 2QH, UK.


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Membrane-mediated cytotoxicity Download PDF EPUB FB2

Read "Membrane‐mediated cytotoxicity, Journal of Cellular Biochemistry" on DeepDyve, the largest online rental service for scholarly research with thousands of Membrane-mediated cytotoxicity book publications available at your fingertips.

Benjamin Bonavida and R. John Collier, Organizers March 9 - Ma Plenary Sessions March Cytotoxic Proteins: Structure. Membrane-Mediated Cytotoxicity: Measurement of Changes and their Prevention by Divalent CationsCited by: 1.

Grace T., Ehrlich Y.H., Tritton T.R. () Mechanisms of Membrane-Mediated Cytotoxicity by Adriamycin. In: Chandra P. (eds) New Experimental Modalities in the Control Membrane-mediated cytotoxicity book Neoplasia. NATO ASI Series (Series A: Life Sciences), vol Cited by: 3.

Protection against membrane-mediated cytotoxicity by calcium and zinc Article (PDF Available) in American Journal Of Pathology (3). Mechanisms of Membrane-Mediated Cytotoxicity by Adriamycin.

Pages Grace, Thomas (et al.) *immediately available upon purchase as print book shipments may be delayed due to the COVID crisis. ebook access is temporary and does not include ownership of the ebook.

Only valid for books with an ebook version. Injection of S. aureus alpha toxin or ultraviolet-inactivated Sendai virus into the mammary gland of lactating mice leads to cytopathic changes in the alveolar cells compatible with a breakdown of their permeability barrier.

Simultaneous administration. The book describes the structure and biosynthesis of the glycoproteins in relation to known or postulated functions in membranes.

The text opens with an introduction and a topic on detection and distribution of membrane glycoproteins. The book then notes that the isolation of membrane glycoproteins brought by the progress in research and technology of membrane.

T cell-mediated cytotoxicity All viruses, and some bacteria, multiply in the cytoplasm of infected cells; indeed, the virus is a highly sophisticated parasite that has no biosynthetic or metabolic apparatus of its own and, in consequence, can replicate only inside cells.

TAM-membrane mediated cytotoxicity, we per-formed studies of TAM perturbations on growth, in the presence of Ca 2+and Mg and on the physi-cal properties of bacterial phospholipid membranes in the presence of Ca2+, a natural membrane stabil-izer (Jurado et al., ; Livingstone and Schachter, ; Mosley et al., ).

MATERIALS AND METHODS. Amyloid-β peptide (Aβ)–membrane interactions have been implicated in the formation of toxic oligomers that permeabilize membranes, allowing an influx of calcium ions and triggering cell death in the pathogenesis of Alzheimer’s disease (AD).

Curcumin, a small dietary polyphenolic molecule, has been shown to reduce Aβ-induced toxicity and AD pathology. We investigate. The chapter explains the interaction between the cell membrane and NPs to show how NPs serve as carriers for drug delivery and induce cytotoxicity.

These studies explains the mechanisms for NPs interacting with the plasma membrane, which help to understand the cytotoxicity of NPs and guide to design new NPs for drug delivery.

Membrane-mediated cytotoxicity. New York: Liss, © (OCoLC) Online version: Membrane-mediated cytotoxicity. New York: Liss, © (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors: Benjamin Bonavida; R John Collier. To further clarify the physicochemical basis of TAM-membrane mediated cytotoxicity, we performed studies of TAM perturbations on growth, in the presence of Ca 2+ and Mg 2+ and on the physical properties of bacterial phospholipid membranes in the presence of Ca 2+, a natural membrane stabilizer (Jurado et al., ; Livingstone and Schachter.

Article Membrane-Mediated Regulation of the Intrinsically Disordered CD3e Cytoplasmic Tail of the TCR Cesar A. Lo´pez,1 Anurag Sethi,2 Byron Goldstein,1 Bridget S.

Wilson,3 and S. Gnanakaran1,4 * 1Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico; 2Department of Molecular Biophysics and Biochemistry, Yale.

Another form of type II hypersensitivity is called antibody-dependent cell-mediated cytotoxicity (ADCC). Here, cells exhibiting the foreign antigen are tagged with antibodies (IgG or IgM). These tagged cells are then recognised by natural killer (NK) cells and macrophages (recognised via IgG bound (via the Fc region) to the effector cell.

The t 50 for membrane-mediated Aβ self-assembly was ± h (Figure 2I), in agreement with previous reports of retarded Aβ fiber formation in the presence of neutral or charged membranes.

68, 69 This is attributed to hydrophobic and—in the case of anionic lipids—electrostatic interactions between monomeric Aβ peptides and the lipid. While antibacterial and antifungal assays are of great importance, the potential for ILs to damage host cell membranes is a significant concern relating to potential cytotoxicity.

Red blood cell (RBC) membranes are generally known to be relatively “fragile” and thus are often used as a model system for membrane-mediated cytotoxicity [51,52].

Investigations of the interactions between nanoparticles and lipid bilayer may yield insight into the understanding of the protein-biomembrane interactions and the cytotoxicity of drugs. Membrane-mediated cytotoxicity: Proceedings of a Cetus-UCLA Symposium held in Park City, Utah, March(UCLA symposia on molecular and cellular biology) by Benjamin Bonavida, R.

John Collier and a great selection of related books, art and collectibles available now at Pharmaceutical particulates and membranes possess promising prospects for delivering drugs and bioactive molecules with the potential to improve drug delivery strategies like sustained and controlled release.

For example, inorganic-based nanoparticles such as silica- titanium- zirconia- calcium- and carbon-based nanomaterials with dimensions smaller than nm have been. Book: All Authors / Contributors: Eric Reid; G M W Cook; J P Luzio. Find more information about: ISBN: OCLC Number: Notes: "Based on the proceedings of the 10th International Subcellular Methodology Forum, held September, at the University of Surrey, in Guildford, United Kingdom"--Title page verso.Antibody-dependent cellular cytotoxicity (ADCC), also referred to as antibody-dependent cell-mediated cytotoxicity, is a mechanism of cell-mediated immune defense whereby an effector cell of the immune system actively lyses a target cell, whose membrane-surface antigens have been bound by specific antibodies.

It is one of the mechanisms through which antibodies, as part of .Nanoparticle penetration into cell membranes is an interesting phenomenon that may have crucial implications on the nanoparticles’ biomedical applications.

In this paper, a coarse-grained model for gold nanoparticles (AuNPs) is developed (verified against experimental data available) to simulate their interactions with model lipid membranes.